Figure 1
From: Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
Schematic of huntingtin protein. Schematic shows locations of epitope for Ab1 antibody (aa1-17) and mAb 2B7 (aa1-17) and the polyglutamine region (black box). Membrane binding is contributed by aa1-17 [44], the poly-proline region (gray box, [45]) and aa172-372 (white box, [62]). Regions of calpain and caspase cleavage are represented by arrows. Approximate regions of cpA and cpB cleavage are also marked by arrows. Shown below are three huntingtin cDNA constructs used in this study.