Figure 4
From: Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
The chemical structures for select aspartyl proteases. Compounds P1-N031, P1-N034 and P1-N039 were effective at inhibiting cpA in clonal striatal cells. Compound P1-N031 has greater specificity for cathepsin D and cathepsin E compared to BACE 1 and BACE 2 whereas compound P1-N038 which was ineffective at blocking cpA has greater specificity for BACE 1 and BACE 2 (see also Table 1).