Figure 5

Aβ-induced paralysis in C. elegans strain CL2006 fed with choline analogs, JAY2-22-33 and JWB1-84-1. (A) Effect of JAY2-22-33 at concentration of 10 nm, 100 nm, 1 μM, 10 μM and 100 μM on Aβ-induced paralysis. (B) Effect of JWB1-84-1 at concentration 10 nm, 100 nm, 1 μM, 10 μM and 100 μM on Aβ-induced paralysis. Synchronized eggs of CL2006 C. elegans were maintained at 20°C, on the 35 × 10 mm culture plates (~35 eggs/plate) containing vehicle (control) or compound. The treatment was given to the worm from egg stage onward until the worm completely paralyzed (35 worms in each experiment, 3 independent experiments). n.s. = not significant