The three treatments had significantly different effects on nuclear NICD levels and dendritic degeneration in the cortex. A. Western blot analysis shows nuclear NICD levels from prion infected CD1 mice after treatment with Qa alone, GSI alone and Qa + GSI. For controls, nuclear NICD levels in an uninfected mouse (Control, C) and in an untreated RML prion infected mouse (UnTx) are shown. B. Relative NICD levels are plotted as a function of dendritic load (see Fig. 9D). See text for discussion. Error bars for both dendrite load and NICD (n = 3 mice each) are shown .