Combined GSI + Qa therapy reduced rPrPSc in prion infected CD1 mice by 95% in the neocortex and hippocampus and by 50% in the thalamus. Western immunoblots of rPrPSc in the neocortex (A), hippocampus (B), and thalamus (C) are shown. Adjacent bar graphs show densitometry estimates of the relative rPrPSc levels in the respective Western blots (integrated optical density units per milligram of total protein). Means and standards deviation are shown. Student's t test probability (n = 3 mice each): * P ≤ 0.05; ** P ≤ 0.01. Adapted from Spilman et al. .