Figure 11

Combined GSI + Qa therapy reduced rPrP^Sc in prion infected CD1 mice by 95% in the neocortex and hippocampus and by 50% in the thalamus. Western immunoblots of rPrP^Sc in the neocortex (A), hippocampus (B), and thalamus (C) are shown. Adjacent bar graphs show densitometry estimates of the relative rPrP^Sc levels in the respective Western blots (integrated optical density units per milligram of total protein). Means and standards deviation are shown. Student's t test probability (n = 3 mice each): * P ≤ 0.05; ** P ≤ 0.01. Adapted from Spilman et al. [8].