Progressive degeneration of dendrites during prion disease occurs early in the incubation time . CD1 mice were inoculated in the thalamus with RML scrapie prions. A. Representative Golgi silver impregnation of dendrites in the neocortex show severe atrophy in scrapie-infected mice compared to controls. B. Apical dendritic length versus incubation time in age matched controls (open circles) and in scrapie (closed circles) is shown during the course of scrapie. Adapted from Ishikura et al. .