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Figure 1 | Molecular Neurodegeneration

Figure 1

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Figure 1

Cell cycle markers are present in cerebellar dentate nuclear neurons in material from cases with human AD. Immunostaining for cyclin A, Cdk4 and PCNA are indicated by black arrows in controls (A, C, E) and AD cases (B, D, F). (A-B) Cyclin A (arrows) was found in the nucleus of neurons in the cerebellar dentate nucleus in some AD cases but not controls. The brown material is lipofuscin. (C-D) Strong nucleolar staining of Cdk4, against a background of clear nucleoplasm (arrows), was more prevalent in AD material (D) than in control (C). (E-F) PCNA immunostained neurons were found in the cerebellar dentate nucleus, but controls (E) and AD cases (F) showed no significant difference.

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Molecular Neurodegeneration

ISSN: 1750-1326