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Figure 2 | Molecular Neurodegeneration

Figure 2

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Figure 2

Evidence of DNA damage can be detected in AD cerebellar deep nuclear neurons and surrounding non-neuronal cells. (A-B) 53BP1 staining is virtually absent in control material (A) but robust in neurons of the AD cases (B); (C-D) Phosphorylated S1981 ATM (P-ATM) is much less prominent in control (C) than in AD (D) material; (E-F) Phosphorylated T68 of the cell cycle checkpoint kinase, Chk2 (P-Chk2) is less apparent in control (E) than in AD (F) material, but the cells that are stained in the AD deep nucleus are most likely astrocytes, not neurons. The insert in F validates this interpretation. Its shows double staining of P-Chk2 (red) and GFAP (green), an astrocyte marker.

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