Figure 2From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's diseaseEvidence of DNA damage can be detected in AD cerebellar deep nuclear neurons and surrounding non-neuronal cells. (A-B) 53BP1 staining is virtually absent in control material (A) but robust in neurons of the AD cases (B); (C-D) Phosphorylated S1981 ATM (P-ATM) is much less prominent in control (C) than in AD (D) material; (E-F) Phosphorylated T68 of the cell cycle checkpoint kinase, Chk2 (P-Chk2) is less apparent in control (E) than in AD (F) material, but the cells that are stained in the AD deep nucleus are most likely astrocytes, not neurons. The insert in F validates this interpretation. Its shows double staining of P-Chk2 (red) and GFAP (green), an astrocyte marker.Back to article page