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Figure 3 | Molecular Neurodegeneration

Figure 3

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Figure 3

Cyclin A expression negatively correlates with 53BP1 or P-ATM expression in cerebellar dentate nuclei. Two sections from an AD patient were first stained with cell cycle marker Cyclin A (CycA), then stained with DNA damage markers 53BP1 or P-ATM. Staining of Cyclin A was visualized by peroxidase substrate DAB (brown staining, red arrow). 53BP1 (left panels) or P-ATM (right panels) was visualized by Vector VIP (purple staining, black arrow) or Vector blue (blue staining, blue arrow). Cyclin A and the DNA damage markers 53BP1 or P-ATM were consistently found in different CDN neurons, the insets represent high magnification reproductions of the cells indicated by the arrows in the main panel.

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