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Figure 4 | Molecular Neurodegeneration

Figure 4

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Figure 4

The incidence of hyperploidy is high in dentate nucleus neurons from both AD and control samples. Figures A-C show a representative polyploid cerebellar dentate nuclear neuron. (A) FISH probe fluorescence (green spots) indicates three genomic copies of the probe. The red color is due to the autofluorescence of the neuronal lipofuscin. (B) DAPI counterstain shows the location of the nucleus. (C) Merge of A and B. (D) Bar graph shows the results of scoring of about 100 neurons per case for the presence of 3-4 spots in a single dentate neuronal nucleus. The t-test statistic indicates that there is no significant difference (p = 0.9) between controls (15.2 ± 4.4%) and AD (13.5 ± 6.1%).

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Molecular Neurodegeneration

ISSN: 1750-1326