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Figure 5 | Molecular Neurodegeneration

Figure 5

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Figure 5

A comparison of various neuronal stress markers in the CDN of AD, PSP (progressive supranuclear palsy) and control. Top row: while hyperphosphorylated tau (AT8 staining) is absent in control (column 1) and AD (column 2) samples of CDN, its expression in PSP neurons (column 3) is quite strong. Second row: the reverse pattern is found for the DNA damage response (P-ATM). DNA damage is prevalent in AD but absent in PSP; control samples are negative. Third row: cell cycle reentry (CycA immunostaining) reveals yet a different pattern; it is absent in controls, but present in CDN neurons of both AD and PSP. Fourth row: the cell death marker, cleaved caspase 6 (cCasp6) appears to reproduce the pattern seen with the cell cycle markers; clear neuronal staining in both AD and PSP.

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Molecular Neurodegeneration

ISSN: 1750-1326