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Table 2 DNA damage responses and cell cycle events correlate with AD disease state

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Immunohistochemistry

AD

cases

Control

cases

Fisher's Exact test

p(< 0.05)

Chi-square with Yates correction

     

κ2

p(< 0.05)

Cyclin A

+

14

1

0.0002

11.88

0.0006

 

-

8

17

   

PCNA

+

13

8

0.34

0.59

0.44

 

-

8

10

   

Cdk4

+

18

5

0.0009

9.83

0.002

 

-

2

10

   

53BP1

+

14

4

0.01

5.88

0.015

 

-

8

15

   

P-ATM

+

12

1

0.0001

16.1

0.0001

 

-

2

15

   
  1. Cases marked "+" represent positively stained cases with scores between 1 and 5; cases marked "-" represent those with scores of 0
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Molecular Neurodegeneration

ISSN: 1750-1326