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Table 3 Cell cycle and DNA damage markers in early Alzheimer's disease

From: DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Cerebelar Nuclei

Case

Con/AD

Cyclin A

pATM1981

53BP1

HCB03

AD(0.5)

0

0

0

HCB04

AD(0.5)

0

0

0

HCB07

AD(0.5)

0

0

3

HCB08

AD(0.5)

0

0

0

HCB11

AD(0.5)

5

1

0

Hippocampus

Case

Con/AD

Cyclin A

pATM1981

53BP1

HCB03

AD(0.5)

2

4

3

HCB04

AD(0.5)

2

3

2

HCB07

AD(0.5)

1

4

3

HCB08

AD(0.5)

1

1

1

HCB11

AD(0.5)

1

4

5

  1. Five cases of early AD from the Washington University at St. Louis ADRC were stained for the presence of cell cycle proteins and DNA damage markers in the cerebellar dentate nuclei and hippocampus. Each sample was scored based on % of CDN neurons stained and the staining intensity.