Figure 5
From: Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
Cleavage sequence comparison among BACE1 substrates. A black arrow indicates the currently characterized BACE1 cleavage sites of BACE1 substrates. Amino acid preferences around the BACE1 cleavage sites were determined by Turner R.T. et al. [24]. Interestingly, human Navβ2 harbors the preferable residues at S1 and S1', the most important positions for BACE1 recognition and cleavage.