Skip to main content
Figure 1 | Molecular Neurodegeneration

Figure 1

From: Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

Figure 1

The SorL1 cytoplasmic tail contains multiple putative kinase recognition motifs. Analysis of the SorL1 cytoplasmic domain using phospho-motif software that reports the presence of literature-derived consensus recognition motifs for protein kinases [28] revealed multiple putative phosphorylation sites. Recognized motifs include three for PKC/PKA [R/K XX S/T] [S/T X R/K] at 2167, 2183 and 2178 (bold black) and three for CK2 [S/T XX E/D] at 2167, 2187, 2206 (circled bold black) and one for ROCK2 (circled).

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326