Network diagram of the model. A Reactions involved in p53 and Mdm2 turnover, and the interaction of p53 with GSK3β. Not all reactions involving Mdm2 degradation are included as these are similar to the reactions for p53. B Reactions involved in tau turnover and aggregation. C Reactions involved in Aβ production and aggregation, and the DNA damage response. Important reactions for this model are shown in red. Dashed lines from a species indicate that the species is a modifier of the reaction. Reaction numbers correspond to the numbers in the first column of Tables 2 and 3.