Model output for normal (unstressed) conditions. A-D Four individual simulations over 30 hour time period. E Mean (solid lines) and standard deviation (dashed lines) of 100 simulations. F Deterministic solution from Cell Designer. All parameter values used are given in Tables 2 and 3. Levels of p53 (total pool, including bound and ubiquitinated species), Mdm2 (total pool, including bound and ubiquitinated species), p53 bound to GSK3β, damaged DNA (damDNA), Aβ plaques and Tau tangles are shown. Key: green line: p53, red line: Mdm2, gray line: GSK3b_p53, purple line: damaged DNA, blue line: Tau tangles, cyan line: Abeta plaques.