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Table 2 Reactions involving Gsk3β, Aβ and tau

From: GSK3 and p53 - is there a link in Alzheimer's disease?

No. Name Reactants and products Kinetic Lawa Parameter value
1 GSK3b_p53Binding GSK3b+p53→
GSK3b_p53
kbinGSK3bp53<#GSK3b><#p53> 2.0E-6 molecule-1 s-1
2 GSK3b_p53Release GSK3b_p53→ GSK3b+p53 krelGSK3bp53<#GSK3b_p53> 2.0E-3 s-1
(1) GSK3b_p53_PBinding GSK3b+p53_P→
GSK3b_p53_P
kbinGSK3bp53<#GSK3b><#p53_P> 2.0E-6 molecule-1 s-1
(2) GSK3b_p53_PRelease GSK3b_p53_P→ GSK3b+p53_P krelGSK3bp53<#GSK3b_p53_P> 2.0E-3 s-1
3 Mdm2mRNASynthesis3 GSK3b_p53→
GSK3b_p53+Mdm2mRNA
ksynMdm2mRNAGSK3bp53<#GSK3b_p53> 7.0E-4 s-1
(3) Mdm2mRNASynthesis4 GSK3b_p53_P→
GSK3b_p53_P+Mdm2mRNA
ksynMdm2mRNAGSKbp53<#GSK3b_p53_P> 7.0E-4 s-1
4 Mdm2GSK3phosphorylation1 Mdm2_p53_Ub4+GSK3b→ Mdm2_P1_p53_Ub4+GSK3b kphosMdm2GSK3b<#Mdm2_p53_Ub4> <#GSK3b> 5.0E-3 molecule-1 s-1
5 Mdm2GSK3phosphorylation2 Mdm2_p53_Ub4+GSK3b_p53 → Mdm2_P1_p53_Ub4 +GSK3b_p53 kphosMdm2GSK3bp53<#Mdm2_p53_Ub4> <#GSK3b_p53> 5.0E-1 molecule-1 s-1
(5) Mdm2GSK3phosphorylation3 Mdm2_p53_Ub4+GSK3b_p53_P→ Mdm2_P1_p53_Ub4+GSK3b_p53_P kphosMdm2GSK3bp53<#Mdm2_p53_Ub4> <#GSK3b_p53_P> 5.0E-1 molecule-1 s-1
6 TauSynthesis Source→Tau k synTau 8.0E-5 molecule s-1
7 TauProteasomeBinding Tau+Proteasome→Proteasome_Tau k binTauProt <#Tau><#Proteasome> 1.9E-7 molecule-1 s-1
8 TauDegradation Proteasome_Tau→Proteasome k degTau <#Proteasome_Tau> 1.0E-2 s-1
9 TauMTbinding Tau→MT_Tau k binMTTtau <#Tau> 1.0E-1 s-1
10 TauMTrelease MT_Tau→Tau k relMTTau <#MT_Tau> 1.0E-4 s-1
11 Tauphosphorylation1 GSK3b_p53+Tau→GSK3b_p53+Tau_P1 kphospTauGSK3bp53<#GSK3b_p53><#Tau> 1.0E-1 molecule-1 s-1
(11) Tauphosphorylation2 GSK3b_p53+Tau_P1→GSK3b_p53+Tau_P2 kphospTauGSK3bp53<#GSK3b_p53> <#Tau_P1> 1.0E-1 molecule-1 s-1
(11) Tauphosphorylation3 GSK3b_p53_P+Tau→GSK3b_p53_P+
Tau_P1
kphospTauGSK3bp53<#GSK3b_p53_P><# Tau> 1.0E-1 molecule-1 s-1
(11) Tauphosphorylation4 GSK3b_p53_P + Tau_P1→GSK3b_p53_P+ Tau_P2 kphospTauGSK3bp53<# GSK3b_p53_P> <#Tau_P1> 1.0E-1 molecule-1 s-1
12 Tauphosphorylation5 GSK3b+Tau→GSK3b+Tau_P1 kphospTauGSK3b<#GSK3b><#Tau> 2.0E-4 molecule-1 s-1
(12) Tauphosphorylation6 GSK3b+Tau_P1→GSK3b+Tau_P2 kphospTauGSK3b<#GSK3b><#Tau_P1> 2.0E-4 molecule-1 s-1
(13) Taudephosphorylation1 Tau_P2+PP1→Tau_P1+PP1 k dephospTau <#Tau_P2><#PP1> 1.0E-2 molecule-1 s-1
14 TauAggregation1 2Tau→2AggTau k aggTau <# Tau><#(Tau-1)>/2.0 1.0E-8 molecule-1 s-1
(14) TauAggregation2 Tau+AggTau→2AggTau k aggTau <#Tau><#AggTau> 1.0E-8 molecule-1 s-1
15 TauP1Aggregation1 2Tau_P1→2AggTau kaggTauP1 <#Tau_P1><#(Tau_P1-1)>/2.0 1.0E-8 molecule-1 s-1
(15) TauP1Aggregation2 Tau_P1+AggTau→2AggTau kaggTauP1 <# Tau_P1><#AggTau> 1.0E-8 molecule-1 s-1
(15) TauP2Aggregation1 2Tau_P2→2AggTau kaggTauP2 <#Tau_P2><# (Tau_P2-1)>/2.0 1.0E-7 molecule-1 s-1
(15) TauP2Aggregation2 Tau_P2 + AggTau→2AggTau kaggTauP2 <#Tau_P2><# AggTau> 1.0E-7 molecule-1 s-1
16 TangleFormation1 2AggTau→2NFT k tangfor <#AggTau><#(AggTau-1)>/2.0 1.0E-3 molecule-1 s-1
(16) TangleFormation2 AggTau+NFT→2NFT k tangfor <#AggTau><#NFT> 1.0E-3 molecule-1 s-1
17 ProteasomeInhibitionAggTau AggTau+Proteasome→
AggTau_Proteasome
k inhibprot <#AggTau><#Proteasome> 1.0E-5 molecule-1 s-1
18 Abetaproduction1 GSK3b_p53→Abeta+GSK3b_p53 k prodAbeta <#GSK3b_p53> 5.0E-5 s-1
(18) Abetaproduction2 GSK3b_p53_P→Abeta
+GSK3b_p53_P
k prodAbeta <#GSK3b_p53_P> 5.0E-5 s-1
19 AbetaDegradation Abeta→Sink k degAbeta <#Abeta> 1.0E-4 s-1
20 AbetaAggregation1 2Abeta→AggAbeta k aggAbeta <#Abeta><#(Abeta-1)>/2.0 1.0E-8 molecule-1 s-1
(20) AbetaAggregation2 Abeta+AggAbeta→2AggAbeta k aggAbeta <#Abeta><#AggAbeta> 1.0E-8 molecule-1 s-1
21 AbetaPlaqueFormation1 2AggAbeta→2AbetaPlaque k pf <#AggAbeta><#(AggAbeta-1)>/2.0 1.0E-3 molecule-1 s-1
(21) AbetaPlaqueFormation2 AggAbeta+AbetaPlaque→2AbetaPlaque k pf <#AggAbeta><#AbetaPlaque> 1.0E-3 molecule-1 s-1
22 ProteasomeInhibitionAbeta AggAbeta+Proteasome→
AggAbeta_Proteasome
k inhibprot <#AggAbeta><#Proteasome> 1.0E-5 molecule-1 s-1
23 p53transcriptionViaAbeta Abeta→p53_mRNA+Abeta ksynp53mRNAAbeta<#Abeta> 1.0E-5 s-1
24 AbetaROSproduction1 AggAbeta→AggAbeta + ROS k genROSAbeta <#AggAbeta> 1.0E-5 s-1
24 AbetaROSproduction2 AggAbeta_Proteasome→AggAbeta_Proteasome + ROS k genROSAbeta <#AggAbeta_Proteasome> 1.0E-5 s-1
  1. a <#X> means number of molecules of species X
  2. We assume that the reaction volume is equal to one.
  3. Reactions with number in 1st column are shown in Figure 2; reactions with numbers in parentheses are similar to the reactions shown in Figure 2.