Skip to main content

Table 1 Analysis of covariance of PGC1α single nucleotide polymorphisms

From: Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

Model Localization R2 ΔR2 P value
HD CAG   0.5128   < 0.0001*
HD CAG + PGC-1α     
   rs2970865 promoter region 0.5124 -0.0004 0.6436
   rs17576121 promoter region 0.5187 0.0059 0.0795
   rs2970870 promoter region 0.5180 0.0052 0.0566
   rs7665116 intron 2    
   1-1 vs 1-2 vs 2-2   0.5257 0.0129 0.0389*
   1-1 vs 1-2 + 2-2   0.5256 0.0128 0.0112*
   rs2970848 intron 7 0.5150 0.0022 0.1355
   rs2970847 exon 8 0.5256 0.0128 0.0947
   rs8192678 exon 8 0.5060 -0.0068 0.9863
   rs3755863 exon 8 0.5063 -0.0065 0.0953
  1. The level of significance was set to P = 0.05; n = 854
  2. HD CAG expanded CAG allele in huntingtin