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Table 1 Analysis of covariance of PGC1α single nucleotide polymorphisms

From: Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

Model

Localization

R2

ΔR2

P value

HD CAG

 

0.5128

 

< 0.0001*

HD CAG + PGC-1α

    

   rs2970865

promoter region

0.5124

-0.0004

0.6436

   rs17576121

promoter region

0.5187

0.0059

0.0795

   rs2970870

promoter region

0.5180

0.0052

0.0566

   rs7665116

intron 2

   

   1-1 vs 1-2 vs 2-2

 

0.5257

0.0129

0.0389*

   1-1 vs 1-2 + 2-2

 

0.5256

0.0128

0.0112*

   rs2970848

intron 7

0.5150

0.0022

0.1355

   rs2970847

exon 8

0.5256

0.0128

0.0947

   rs8192678

exon 8

0.5060

-0.0068

0.9863

   rs3755863

exon 8

0.5063

-0.0065

0.0953

  1. The level of significance was set to P = 0.05; n = 854
  2. HD CAG expanded CAG allele in huntingtin