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Table 3 Mean ages-at-onset of the different rs7665116 genotypes in Italian HD patients

From: Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

Genotype

Number of patientsa

Mean CAGexp (SE)

Mean AAO (SE)

T/T

210

45.4 (0.33)

46.58 (0.96)

T/C

97

45.6 (0.45)

49.55 (1.43)

C/C

5

44.6 (0.98)

51.80 (2.25)

  1. CAGexp, expanded CAG repeat number; SE, standard error; T, major allele g.38570T; C, minor allele g.38570C.
  2. an = 312.
  3. t-test: Mean ages-at-onset do not differ significantly between the three genotypes (T/T vs T/C: P = 0.0570; T/T vs C/C: P = 0.4079; T/C vs C/C: P = 0.7596).
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Molecular Neurodegeneration

ISSN: 1750-1326