Skip to main content

Table 5 Mean ages-at-onset of the different rs2970870 genotypes in HD patients with ≤ 55 CAGs

From: Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

Genotype

Number of patientsa

Mean CAGexp (SE)

Mean AAOb (SE)

T/T

262

44.9 (0.21)

46.37 (0.77)

T/C

404

44.5 (0.15)

48.19 (0.62)

C/C

118

45.4 (0.33)

43.67 (1.15)

  1. CAGexp, expanded CAG repeat number; SE, standard error; T, major allele g.-1437T; C, minor allele g.-1437C.
  2. an = 784.
  3. bt-test: Patients ≤ 60 CAG repeats and genotype C/C differ significantly from patients with T/T and T/C genotype (p = 0.0039).
Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326