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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo

Figure 4

APP or APP CTF levels were not significantly altered in mTNFα expressing mice. A-B. Representative anti CT20 immunoblot showing no significant changes in APP or CTFα levels in AAV2/1-mTNFα expressing TgCRND8 compared to age-matched transgenic mice expressing EGFP (control cohort) (A). Intensity analysis of anti CT20 immunoreactive APP and CTFα levels was normalized to β-actin in TgCRND8 mice cohort (B). (n = 3/group). C-D. Representative anti 4G8 immunoblot showing no significant changes in CTFβ levels in AAV2/1-mTNFα expressing TgCRND8 compared to age-matched transgenic mice expressing EGFP (control cohort) (C). Intensity analysis of anti 4G8 immunoreactive CTFβ levels was normalized to β-actin in TgCRND8 mice cohort (D). (n = 3/group). E-F. Representative anti CT20 immunoblot showing no significant changes in APP levels in AAV2/1-mTNFα expressing non transgenic B6C3 mice compared to age-matched non transgenic B6C3 expressing EGFP (E). Intensity analysis of anti CT20 immunoreactive APP levels was normalized to β-actin in the wild type mice cohort (F). (n = 4/group).

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