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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo

Figure 5

Increased levels of immune activation in mTNFα expressing TgCRND8 mice. A-F. Representative sections from the hippocampus of EGFP (A-C) or mTNFα expressing mice (D-F) from 5.5 month old TgCRND8 mice depicting increased clustering of tomato lectin binding activated glia (depicted in red) in close contact with Aβ plaques (depicted in green). Column marked "merged" depicts a merged dual color depiction of the corresponding tomato lectin and Aβ immunostaining. Scale Bar, 25 μm. (n = 3/group). G-J. Two representative sections from the hippocampus of EGFP (G-H) or mTNFα expressing mice (I-J) from 5.5 month old TgCRND8 mice depicting increased MHCII stained cells with the morphology of peripheral monocytes around cored plaques in mTNFα expressing animals. The sections have been counterstained with hematoxylin and Congo Red. Scale Bar, 25 μm. (n = 5/group). K. The number of MHCII immunopositive cells in the immediate proximity of Congophilic Aβ cored plaques were quantified by averaging from at least ten individual plaques from each sample. (*p < 0.05; t test; n = 5/group).

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