Figure 6
From: Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
Comparative analysis of Aβ plaque burden in TgCRND8 mice following acute hippocampal expression of pro-inflammatory cytokines. 4 month old TgCRND8 mice were stereotaxically injected in the hippocampus with either rAAV2/1-IL-6, rAAV2/1-mIFNγ, rAAV2/1-mTNFα or rAAV2/1-EGFP and sacrificed after 6 weeks. Quantification of forebrain Aβ plaque burdens in 5.5 month old mice compared to unmanipulated 4 month old TgCRND8 mice is shown. (*p and **p = 0.0011; one way ANOVA; n = 5-6/group).