Figure 5
From: Differential regulation of BACE1 expression by oxidative and nitrosative signals
SNO-BACE1 levels decrease in late stage AD brains which inversely correlates with BACE1 protein levels. (A) SNO-BACE1 levels were detected by immunoblot analysis following biotin-switch assays in NC, MCI, and AD patient brain samples. Total BACE1 levels were detected by Western blot analysis. (B) Quantification of the Western blots using densitometry analysis reveals a statistically significant elevation of SNO-BACE1 levels in AD brains compared to NC and MCI brains ** indicates P < 0.005.