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Figure 1 | Molecular Neurodegeneration

Figure 1

From: TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons

Figure 1

Effect of TTR on calcium. Cultures of DRG neurons were treated with L55P (A) or wild-type (B) TTR and intracellular calcium flux (ΔF/F0) was measured over a 500 sec time course. Addition of L55P elicited greater calcium fluxes than WT. Significantly, calcium entry at growth cones (arrows) occurred earlier than at DRG cell soma. Scale bar is 5 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326