Figure 9From: 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell deathModel of Puma action in response to 6-OHDA. In this model, 6-OHDA-induced ROS production causes both DNA and protein damage. Oxidative protein damage activates UPR, leading to the upregulation of chaperones. DNA damage leads to the activation of the p53 DNA damage repair pathway and p53-mediated Puma upregulation leads to the induction of apoptosis.Back to article page