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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2gene

Figure 6

hSMN2 extends the survival of smnY 262 stop-/-fish. Survival was followed up to 23 dpf and a Kaplan-Meier plot was generated. Tg(hSMN2)os38, purple line, n = 143; Tg(hSMN2)os38; smnY262stop+/-, red line, n = 62; Tg(hSMN2)os38; smnY262stop-/-, green line, n = 25; smnY262stop-/-, blue line, n = 40. The average survival was 12 dpf (range = 7-15 dpf) for smnY262stop-/-larvae and 14.7 dpf (range = 10-17 dpf) for Tg(hSMN2)os38; smnY262stop-/-(p < 0.0001).

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