Figure 4

Dynein mutation increases liver IGF-1 expression. A- mRNA levels of Insulin-like growth factor (IGF-1) in the liver of wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns) *P < 0.05 versus Wt; #, p < 0.05 as indicated. N = 9 mice per group. B- mRNA levels of Insulin-like growth factor (IGF-1) and its muscle specific splice variant mechano-growth factor (MGF) in the gastrocnemius muscle of wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns). N = 9 mice per group. C- Serum IGF-1 levels in wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns) #, p < 0.05 as indicated. Note that circulating IGF-1 levels are increased in dynein mutant mice and that this increase is abolished in compound SOD1(G93A)/Cra mice. N = 9 mice per group.