Figure 1
From: Biology and pathophysiology of the amyloid precursor protein
Comparison of protein sequences of C. elegans APL-1, Drosophila APPL, Zebrafish APPa, Xenopus APP-A and the human APP, APLP1 and APLP2. Purple sequences indicate identical homology while green references similar amino acids. Homologous regions include the E1 domain (light blue line), E2 domain (yellow line) and sequences within the C-terminus such as the conserved Thr site (arrow head) and YENPTY motif (black box). The transmembrane domain and Aβ sequence are noted by the blue and red boxes respectively.