Table 1 Candidate gene and SNP characteristics
Gene | Chromosome | SNPs | Selection Criteria | |
|---|---|---|---|---|
ESRRA | 11q13.1 | rs3217060 | 23 bp microsatellite repeat located in promoter region | |
MFN2 | 1p36.22 | rs3753579 | located in promoter region | |
NRF-1 | 7q32.2 | rs7781972, rs6949152 | previously reported association [29] | |
rs1882094, rs3735006, | non-synonymous SNPs | |||
rs10275661, rs10225103, rs10268267, rs6962005, rs10231985, rs11487138, rs11761434, rs1962039, rs2402970, rs6948697, rs10500120 | tag SNPs using public databases (dbSNP) | |||
NRF-2 | GABPA | 21q21.3 | rs2829897 (A291V), rs2829898 (W323X), rs2829900 (E345K) | non-synonymous SNPs |
GABPB1 | 15q21.2 | rs12594956, rs8031031 | previously reported association [39] | |
PPARGC1B | 5q33.1 | rs7732671 (A164P), rs11959820 (R253S) | non-synonymous SNPs | |
PPARG | 3p25.2 | rs1801282 (P12A) | non-synonymous SNP | |
rs2938392, rs3856806 | tag SNPs using public databases (dbSNP) | |||
SIRT1 | 10q21.3 | rs3758391, rs7069102 | previously reported association [40] | |
rs10997860, rs2273773, rs35461348 | tag SNPs using public databases (dbSNP) | |||
TFAM | 10q21.1 | rs1937 (S12T) | non-synonymous SNP | |
rs4390300, rs10826178, rs1049432, rs11006132 | tag SNPs using public databases (dbSNP) | |||