PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

Table 2 Details of SNPs included in the multivariable model

Gene	SNP	Chromosome	Allele Freq.	Type	Biological Processes	ΔR²	Standardized beta
							Coefficients	t	P *
NRF-1	rs7781972	7q32.2	189/170/42	IVS1	control of nuclear genes required for respiration, heme biosynthesis, and mtDNA transcription and replication	.004	-.066	-2.56	.011
	rs6949152		289/101/11	IVS1		.005	-.076	-2.94	.004
TFAM	rs1049432	10q21.1	239/145/17	3' near gene	mtDNA transcription and maintenance factor	.002	-.053	-2.04	.042
	rs11006132		208/170/23	3' near gene		.004	-.063	-2.45	.015
PPARGC1A	rs7665116	4p15.2	309/82/10	IVS2	transcriptional coactivator, regulation of key mitochondrial genes	.004	-.065	-2.52	.012
CO1	C7028T	mt7028	207/194	mitochondrial	component of the respiratory chain, catalyses the reduction of oxygen to	.003	-.057	-2.22	.027

The variability in motoric AO attributable to the CAG repeat length was assessed by linear regression using the logarithmically transformed onset age as the dependent variable and genotypes as independent variables. Delta (Δ) R²quantifies the relative improvement of the regression model when the genotypes are considered in addition to the CAG repeats. * nominal P-values (not adjusted for multiple testing)

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