PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

Table 3 SNP-SNP interaction included in final multivariable model

Interaction	R²	Adjusted R²	ΔR²	Standardized beta
				Coefficients	t	P
CAG	.730	.729		-.864	-34.23	<0.0001
NRF-1 rs6949152 * CO1 C7028T	.739	.738	.009	-.090	-3.55	<0.0001
NRF-1 rs7781972 * TFAM rs11006132	.745	.743	.014	-.077	-3.03	<0.003
PPARGC1A rs7665116	.749	.747	.018	-.069	-2.72	<0.007

A multivariable model including a total of four interactions was built in the total HD cohort using forward selection. With the addition of each SNP-SNP interaction, along with each SNP's respective main effect, the variability in adjusted log motor AO increased (assessed by adjusted R²). The final multivariable model explains 4.8% additional residual variance in HD motor AO.

ISSN: 1750-1326