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Table 3 SNP-SNP interaction included in final multivariable model

From: PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

Interaction R2 Adjusted R2 ΔR2 Standardized beta
     Coefficients t P
CAG .730 .729   -.864 -34.23 <0.0001
NRF-1 rs6949152 * CO1 C7028T .739 .738 .009 -.090 -3.55 <0.0001
NRF-1 rs7781972 * TFAM rs11006132 .745 .743 .014 -.077 -3.03 <0.003
PPARGC1A rs7665116 .749 .747 .018 -.069 -2.72 <0.007
  1. A multivariable model including a total of four interactions was built in the total HD cohort using forward selection. With the addition of each SNP-SNP interaction, along with each SNP's respective main effect, the variability in adjusted log motor AO increased (assessed by adjusted R2). The final multivariable model explains 4.8% additional residual variance in HD motor AO.