Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

Table 1 Stage 1 Analysis of RA-SNPs Association with AD

CHR	SNP	Gene	RA OR	RA P-value	AD OR [96% CI]	AD P-value	BF p-value
21	rs2837960	BACE2	1.05	2 × 10^-6	1.29 [1.10-1.52]	0.002	0.03
9	rs3761847	TRAF1, C5	1.32	4 × 10^-14	1.19 [1.05-1.35]	0.006	0.11
18	rs2002842	SALL3	1.61	6 × 10^-6	1.15 [1.01-1.31]	0.04	0.65
9	rs881375	TRAF1, C5	NR	4 × 10^-8	1.11 [0.97-1.26]	0.12
6	rs660895	HLA-DRB1	3.62	1 × 10^-108	0.93 [0.80-1.09]	0.39
12	rs3184504	SH2B3	0.92	6 × 10^-6	0.95 [0.84-1.08]	0.41
8	rs2736340	BLK	1.19	6 × 10^-9	0.95 [0.82-1.10]	0.47
2	rs13031237	REL	1.13	8 × 10^-7	1.04 [0.92-1.19]	0.52
6	rs6457617	HLA-E	2.36	5 × 10^-75	1.03 [0.91-1.17]	0.61
4	rs13119723	IL2, IL21	1.12	7 × 10^-7	0.96 [0.80-1.14]	0.62
2	rs13017599	REL	1.21	2 × 10^-12	1.03 [0.90-1.17]	0.67
9	rs951005	CCL21	0.81	4 × 10^-10	1.03 [0.87-1.22]	0.73
6	rs6910071	HLA-DRB1	2.88	1 × 10^-299	0.98 [0.84-1.14]	0.75
1	rs2476601	PTPN22	1.94	9 × 10^-74	1.03 [0.84-1.27]	0.77
7	rs10488631	IRF5	1.19	4 × 10^-11	0.99 [0.81-1.20]	0.91
2	rs231735	CTLA4	0.83	6 × 10^-9	1.01 [0.89-1.14]	0.91
1	rs3890745	TNFRSF14	0.88	4 × 10^-6	0.99 [0.87-1.13]	0.93

Seventeen SNPs exhibiting genome-wide significant associations with RA were tested for their association with AD risk using allelic models in a Mayo Clinic AD GWAS series of 843 AD and 1264 non-AD individuals. Three of the seventeen RA-associated SNPs were nominally associated with AD (p < 0.05). Multiple testing was addressed by applying a Bonferroni (BF) correction for the number of tests performed. The only SNP that retained significance after BF correction was rs2837960 (p = 0.03). NR = value not reported in initial study.

ISSN: 1750-1326