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Table 1 Stage 1 Analysis of RA-SNPs Association with AD

From: Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

CHR SNP Gene RA OR RA P-value AD OR [96% CI] AD P-value BF p-value
21 rs2837960 BACE2 1.05 2 × 10-6 1.29 [1.10-1.52] 0.002 0.03
9 rs3761847 TRAF1, C5 1.32 4 × 10-14 1.19 [1.05-1.35] 0.006 0.11
18 rs2002842 SALL3 1.61 6 × 10-6 1.15 [1.01-1.31] 0.04 0.65
9 rs881375 TRAF1, C5 NR 4 × 10-8 1.11 [0.97-1.26] 0.12  
6 rs660895 HLA-DRB1 3.62 1 × 10-108 0.93 [0.80-1.09] 0.39  
12 rs3184504 SH2B3 0.92 6 × 10-6 0.95 [0.84-1.08] 0.41  
8 rs2736340 BLK 1.19 6 × 10-9 0.95 [0.82-1.10] 0.47  
2 rs13031237 REL 1.13 8 × 10-7 1.04 [0.92-1.19] 0.52  
6 rs6457617 HLA-E 2.36 5 × 10-75 1.03 [0.91-1.17] 0.61  
4 rs13119723 IL2, IL21 1.12 7 × 10-7 0.96 [0.80-1.14] 0.62  
2 rs13017599 REL 1.21 2 × 10-12 1.03 [0.90-1.17] 0.67  
9 rs951005 CCL21 0.81 4 × 10-10 1.03 [0.87-1.22] 0.73  
6 rs6910071 HLA-DRB1 2.88 1 × 10-299 0.98 [0.84-1.14] 0.75  
1 rs2476601 PTPN22 1.94 9 × 10-74 1.03 [0.84-1.27] 0.77  
7 rs10488631 IRF5 1.19 4 × 10-11 0.99 [0.81-1.20] 0.91  
2 rs231735 CTLA4 0.83 6 × 10-9 1.01 [0.89-1.14] 0.91  
1 rs3890745 TNFRSF14 0.88 4 × 10-6 0.99 [0.87-1.13] 0.93  
  1. Seventeen SNPs exhibiting genome-wide significant associations with RA were tested for their association with AD risk using allelic models in a Mayo Clinic AD GWAS series of 843 AD and 1264 non-AD individuals. Three of the seventeen RA-associated SNPs were nominally associated with AD (p < 0.05). Multiple testing was addressed by applying a Bonferroni (BF) correction for the number of tests performed. The only SNP that retained significance after BF correction was rs2837960 (p = 0.03). NR = value not reported in initial study.