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Table 2 Stage 1 Analysis of RA-SNP's Association with AD Corrected for Age, Sex and APOE Genotype

From: Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

CHR SNP OR L95 U95 P
9 rs3761847 1.211 1.054 1.392 0.007
21 rs2837960 1.256 1.051 1.502 0.012
18 rs2002842 1.147 0.995 1.323 0.059
9 rs881375 1.125 0.973 1.300 0.111
6 rs660895 0.903 0.759 1.076 0.254
8 rs2736340 0.920 0.786 1.077 0.298
2 rs13031237 1.067 0.926 1.230 0.372
6 rs6457617 1.056 0.921 1.211 0.435
2 rs13017599 1.055 0.914 1.217 0.467
9 rs951005 1.060 0.880 1.278 0.539
6 rs6910071 0.949 0.797 1.130 0.558
2 rs231735 1.027 0.895 1.178 0.705
7 rs10488631 0.961 0.774 1.193 0.717
4 rs13119723 0.969 0.800 1.174 0.746
1 rs3890745 1.022 0.882 1.186 0.770
1 rs2476601 1.018 0.811 1.278 0.880
12 rs3184504 0.998 0.869 1.146 0.976
  1. Using logistic regression, SNP-AD associations were corrected for the potential effects of age, sex and APOE genotype (all of which were independent predictors of AD in our Stage 1 analysis). The minor alleles of both rs2837960 and rs3761847 were significantly associated with increased risk of AD (p < 0.05) while the minor allele of rs2002842 exhibited only a trend toward an increased risk of AD.