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Table 2 Stage 1 Analysis of RA-SNP's Association with AD Corrected for Age, Sex and APOE Genotype

From: Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

CHR

SNP

OR

L95

U95

P

9

rs3761847

1.211

1.054

1.392

0.007

21

rs2837960

1.256

1.051

1.502

0.012

18

rs2002842

1.147

0.995

1.323

0.059

9

rs881375

1.125

0.973

1.300

0.111

6

rs660895

0.903

0.759

1.076

0.254

8

rs2736340

0.920

0.786

1.077

0.298

2

rs13031237

1.067

0.926

1.230

0.372

6

rs6457617

1.056

0.921

1.211

0.435

2

rs13017599

1.055

0.914

1.217

0.467

9

rs951005

1.060

0.880

1.278

0.539

6

rs6910071

0.949

0.797

1.130

0.558

2

rs231735

1.027

0.895

1.178

0.705

7

rs10488631

0.961

0.774

1.193

0.717

4

rs13119723

0.969

0.800

1.174

0.746

1

rs3890745

1.022

0.882

1.186

0.770

1

rs2476601

1.018

0.811

1.278

0.880

12

rs3184504

0.998

0.869

1.146

0.976

  1. Using logistic regression, SNP-AD associations were corrected for the potential effects of age, sex and APOE genotype (all of which were independent predictors of AD in our Stage 1 analysis). The minor alleles of both rs2837960 and rs3761847 were significantly associated with increased risk of AD (p < 0.05) while the minor allele of rs2002842 exhibited only a trend toward an increased risk of AD.