Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

Table 4 Combined Stage 1 and Stage 2 Analysis of Top RA-SNPs for Association with AD

Regression Corrected for Age, Sex and APOE						Uncorrected Logistic Regression
CHR	SNP	OR	L95	U95	P	OR	L95	U95	P
21	rs2837960	1.113	1.007	1.230	0.037	1.087	0.974	1.212	0.138
18	rs2002842	1.031	0.952	1.116	0.460	1.017	0.933	1.110	0.699
9	rs3761847	1.011	0.934	1.093	0.793	1.002	0.920	1.091	0.965

Initial analysis of combined Stage 1 and Stage 2 populations revealed that rs2837960 remained overall nominally significant for association with AD per logistic regression (p < 0.05). When this analysis was repeated to include covariate data, rs2837960 showed only a trend for association with AD.

ISSN: 1750-1326