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Table 4 Combined Stage 1 and Stage 2 Analysis of Top RA-SNPs for Association with AD

From: Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

Regression Corrected for Age, Sex and APOE Uncorrected Logistic Regression
CHR SNP OR L95 U95 P OR L95 U95 P
21 rs2837960 1.113 1.007 1.230 0.037 1.087 0.974 1.212 0.138
18 rs2002842 1.031 0.952 1.116 0.460 1.017 0.933 1.110 0.699
9 rs3761847 1.011 0.934 1.093 0.793 1.002 0.920 1.091 0.965
  1. Initial analysis of combined Stage 1 and Stage 2 populations revealed that rs2837960 remained overall nominally significant for association with AD per logistic regression (p < 0.05). When this analysis was repeated to include covariate data, rs2837960 showed only a trend for association with AD.