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Table 6 Analysis of Top RA-SNPs for Association with AD in Combined Stage 1 and Age-Matched Stage 2.

From: Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease

Uncorrected Logistic Regression Regression Corrected for Age, Sex and APOE
CHR SNP OR L95 U95 P OR L95 U95 P
21 rs2837960 1.239 1.083 1.418 0.002 1.199 1.032 1.392 0.018
18 rs2002842 1.056 0.948 1.178 0.323 1.050 0.931 1.184 0.430
9 rs3761847 1.090 0.981 1.210 0.108 1.075 0.958 1.207 0.217
  1. Combined analysis of Stage 1 and Stage 2 data from individuals between 60 and 80 years of age was performed to clarify the association of rs2837960, rs3761847 and rs2002842 with AD risk. The only SNP found to retain a significant association with AD was rs2837960, the G allele of which appears to increase AD risk.