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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

Figure 1

Proteolytic cleavage of PrPC. After cleavage of the N-terminal and GPI anchor signal peptides (grey), mature membrane-bound PrPC can undergo at least three different proteolytic cleavage events (scissors) in addition to phospholipase C cutting within its GPI anchor. While β-cleavage is mainly observed under pathological conditions, a role of ADAM10 is discussed in the context of both, constitutive α-cleavage and shedding of PrPC. The resulting fragments are shown underneath. Striped box: octameric repeat region; checked box: hydrophobic core domain. Epitopes of PrPC specific monoclonal antibodies POM1 and POM2 used in this study are indicated.

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