Figure 5
From: Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Decrease in synaptophysin in mice injected with tau oligomers. Brain sections were stained with antibody to the presynaptic marker synaptophysin (green) nuclear staining with DAPI (blue). All images were taken from the CA1 region. Hemispheres injected with tau oligomers exhibited a decreased in synaptophysin (A). No decrease in the signal was observed in the hemispheres injected with fibrils (B), monomers (C), and PBS (D). (Scale bars = 10 μm.)