Figure 2
From: Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons
BMD preserves RGC morphology in retinas exposed to OHT. (A-C) Representative confocal images of whole-mounted naïve rat retina demonstrating co-localization of CTB (green) with phosphorylated heavy-chain neurofilament (SMI31; red) in RGC axons (dashed lines) and somas (open arrowheads). Similar co-localization was observed in vehicle (D) and BMD (J) control retinas. Vehicle OHT retinas (E-I) demonstrated fewer CTB + RGC somas and axons, dystrophic axons (arrowheads), and swollen RGCs with dendrites accumulating SMI31 (arrows). In BMD OHT retinas (K, L), co-localization of CTB and SMI31 was similar to that in naïve and control retinas. Distance from optic disc is 1 mm (A, D, E, G, J, K), 2 mm (B, H, I), or 4 mm (C, F, L).