Figure 3
From: Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons
BMD preserves CTB uptake by RGCs during OHT. Bar chart shows CTB+ and SMI31+ RGCs as the ratio of OHT to control retina for the vehicle- and BMD-treated rats (mean ± SEM; n = 6 retina each). The naïve group is represented simply as the ratio of the right to left retina. In the vehicle group, OHT decreased the number of CTB+ RGCs so that the ratio was significantly less than one (*, p = 0.01). Treatment with BMD improved CTB uptake in OHT retinas compared to vehicle (**, p < 0.001). The number of SMI31+ RGCs in vehicle-treated retinas was also decreased by OHT, but this result was not significant. The ratio of OHT to control eye for both CTB+ and SMI31+ RGCs was identical for the naïve and BMD-treated rats (p ≥ 0.11).