Figure 4

BMD prevents modest RGC somatic loss with OHT. RGC density is shown for control, vehicle- and BMD-treated groups across eccentricity (mean ± SEM; n = 6 retina each). RGC density decreased with OHT in vehicle retinas compared to control at all locations in each quadrant, with significant decreases indicated (*). In BMD-treated rats, RGC density with OHT was the same as control retinas except at 3 locations in the nasal quadrant (†, p ≤ 0.02) and was significantly higher than vehicle OHT retinas at locations in both temporal and nasal quadrants (§, p ≤ 0.05). Inset: Diagram showing locations in retinal quadrants 1-4 mm eccentric from the optic disc (black circle) for which SMI31+ RGCs were quantified. Size of each field is 0.101mm².