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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons

Figure 7

Deficits in anterograde transport begin in the nasal retina. Retinotopic maps of CTB transport transformed into retinal quadrant and eccentricity coordinates following Siminoff et al. (1966) [27] and Drager and Hubel (1976) [28]. (A) Colliculus maps for naïve (left), vehicle-group control (middle) and BMD-group control (right) eyes are complete (98-99%) and show location of optic disk (*). (B) Moderate transport deficits (shaded regions) in colliculi from vehicle OHT eyes with 58%, 50% and 43% intact transport (left to right respectively) appear to spread from the nasal retinal representation to the optic disk. (C) Moderate to severe transport deficits in vehicle OHT colliculi with 39%, 19% and 2% intact transport (left to right respectively) continue to spread from the optic disk to other retinal quadrants. (D) BMD treatment ameliorates most transport deficits (96% intact, left) but the same spatial pattern of progression applies for even modest deficits (84% and 80% intact, middle and right respectively). Abbreviations: I, N, S, T indicate inferior, nasal, superior and temporal quadrants of the retina, respectively.

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