Figure 1

Aβ42 reduces IGF-1 expression levels, an effect reversed by leptin treatment. (a) Representative Western blot, (b) densitometric analyses, (c) ELISA immunoassay, and (d) Real time RT-PCR analysis show that treatment of organotypic slices with leptin for 72 hours significantly increases basal levels of IGF-1 and reverses Aβ42-induced decrease in IGF-1 expression levels. *p < 0.05, **p < 0.01 and ***p < 0.001 versus control; ^† p < 0.05 and ^{† †} p < 0.01 versus Aβ42.