Selective enhancement of hippocampal-dependent learning and memory in IκBαM/M KI mice. A) No change in activity levels on the open field assay. N = 13-14 mice. B) No change in anxiety-like behavior in light-dark assay. N = 13-14 mice. C) No change in anxiety-like behavior on the elevated plus maze. N = 13-14 mice. D) Increased freezing in response to context but normal freezing in response to cue following conditioned fear training. N = 12-21 mice, * = p < 0.05. E) No difference in latency to find the platform during the Morris water maze training phase. N = 17 mice. F) Both WT and KI mice display preference for the target quadrant during the Morris water maze probe test, however KI mice spend significantly more time in the target quadrant. Dashed line indicates chance performance. N = 17 mice, * = p < 0.05. G) Example traces showing swim path during the probe test. Black squares indicate possible platform locations in each of the quadrants.