Microarray analysis of ERV-expression in BSE-infected compared to non-infected macaques. Fluorescence signal intensities from six BSE-infected macaques were compared to four non-infected controls. Relative expression was calculated as the ratio to the expression of the housekeeping gene HPRT. Results for ERV-E4-1, MacERV-4 and ERV-9 group members Seq60, ERV-9 and Seq59 are shown for basis pontis (A) and vermis cerebelli (B). Statistical significance was analysed using the unpaired students t-test (** p < 0.01; * p < 0.05; ns, not significant). (C) shows non-regulated HERV-L (Seq45) in both brain regions.