Figure 10

Intrastriatal injection of DJ-1-binding compound-23 (comp-23) reduces infarct size after focal cerebral ischemia and reperfusion. (A) Representative photographs showing coronal brain sections at +3, +1, -1, -3, -5, and -7 mm anterior-posterior from the bregma with TTC staining at 1 day after MCAO in sham-operated rats (n = 5) and MCAO-ischemic rats injected with sterilized physiological saline in the presence of the vehicle (4 μL, 1% DMSO, n = 5) or comp-23 (4 nmol/4 μL containing 1% DMSO, n = 4), at 30 min before MCAO (90 min). Scale bar: 1 mm (Sham in A). (B and C) Quantitative analysis of infarct area (B) and volume (C). Data are means ± SEM. Significance (Student's t-test in B; Bonferroni/Dunn post hoc comparisons after ANOVA in C): *P < 0.05, ***P < 0.001 versus sham-operated rats. †P < 0.05, †††P < 0.001 versus vehicle-injected rats.