Figure 3
From: BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina
BBC3 is important for cell death in postnatal retinal neurons. (A) At postnatal day 4, Bbc3-/- retinas have far fewer cleaved CASP3+ (dying) cells compared to wild type retinas (arrows indicate examples of activated CASP3+ cells). (B) The number of CASP3+ cells was significantly different in both the retinal ganglion cell layer and the developing outer retina (P = 0.001; n = 3 for each genotype). Scale bar, 100 μm.