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Figure 6 | Molecular Neurodegeneration

Figure 6

From: BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina

Figure 6

BBC3 is not required for the death of adult retinal ganglion cells (RGCs) after axonal injury. Nissl stained flat mounts of ganglion cell layer (GCL) neurons (left) in Bbc3 deficient mice shows that RGCs are still lost at 7, 14 or 60 days after CONC. Note, only RGCs die after CONC. Approximately 55% of RGC layer neurons are amacrine cellsĀ [27], so a loss of 45% of RGC layer neurons equals complete RGC loss. In contrast to Bbc3 deficiency, Bax deficiency completely protects RGCs from apoptosis after CONC even out to 60 days. N > 5 for each genotype and time point.

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