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Figure 2 | Molecular Neurodegeneration

Figure 2

From: High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

Figure 2

High-level inhibition of complex III activity with myxothiazol is required to increase the rate of glutamate efflux from polarized synaptosomes. Synaptosomes (0.5 mg/ml) were preincubated at 37°C for 5 min. Rates of glutamate release at each concentration of myxothiazol were plotted against percent inhibition of complex III activity brought about by that concentration of myxothiazol. Freehand curves were drawn through the results. Points shown represent the mean ± SEM for experiments carried out in triplicate on at least 3 separate synaptosomal preparations.

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Molecular Neurodegeneration

ISSN: 1750-1326